Tuesday, March 19, 2013

Nature Immunology Contents: April 2013 Volume 14 pp 307 - 413

Nature Immunology

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April 2013 Volume 14, Issue 4

News and Views
Research Highlights


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Regulatory T cells: recommendations to simplify the nomenclature   pp307 - 308
Abul K Abbas, Christophe Benoist, Jeffrey A Bluestone, Daniel J Campbell, Sankar Ghosh, Shohei Hori, Shuiping Jiang, Vijay K Kuchroo, Diane Mathis, Maria Grazia Roncarolo, Alexander Rudensky, Shimon Sakaguchi, Ethan M Shevach, Dario A A Vignali and Steve F Ziegler

News and Views


An inside job for antibodies: tagging pathogens for intracellular sensing   pp309 - 311
Teunis B H Geijtenbeek and Sonja I Gringhuis
Antibodies bound to pathogens that invade cells are sensed in the cytosol by the receptor TRIM21, which triggers innate signaling that leads to protective immunity.

See also: Article by McEwan et al.

T cell priming goes through a new phase   pp311 - 312
David A Blair and Michael L Dustin
The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8+ T cells requires subsequent T cell-T cell interactions during the critical differentiation period.

See also: Article by Gerard et al.

High-affinity IgA needs TH17 cell functional plasticity   pp313 - 315
Pierre J Milpied and Michael G McHeyzer-Williams
The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.

See also: Article by Hirota et al.

How to become your own worst enemy   pp315 - 317
Olivier Voinnet
Persistence is a poorly understood yet widespread outcome of viral infection. A study of RNA viruses in flies now shows that viral fragments endogenized as cDNA during the reverse transcription of retrotransposons provide immunity based on RNA-mediated interference in persistently infected cells.

See also: Article by Goic et al.

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Research Highlights


LncRNA regulates Ifng | Mitochondrial ROS | Tolerating iPSCs | Function of the IgM receptor | Foxp3 phosphorylation | ILC2 cells and metabolic homeostasis



Fishing for mammalian paradigms in the teleost immune system   pp320 - 326
J Oriol Sunyer



Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21   pp327 - 336
William A McEwan, Jerry C H Tam, Ruth E Watkinson, Susanna R Bidgood, Donna L Mallery and Leo C James
During pathogen infection, antibodies can be carried into the cell, where they are detected by the cytosolic antibody receptor TRIM21. McEwan and colleagues show that the recognition of intracellular antibodies by TRIM21 activates immunological signaling.

See also: News and Views by Geijtenbeek & Gringhuis

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination   pp337 - 345
Christiane Pelzer, Katrin Cabalzar, Annette Wolf, Montserrat Gonzalez, Georg Lenz and Margot Thome
The CARM1-MALT1-Bcl-10 complex links ligation of the antigen receptor to NF-κB activation. Thome and colleagues show that MALT1 paracaspase activity requires monoubiquitination at Lys644. Lymphomas with Lys644 mutants have diminished survival.

OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7   pp346 - 355
Myeong Sup Lee, Byungil Kim, Goo Taeg Oh and Young-Joon Kim
The production of type I interferon is regulated by the master transcription factor IRF7. Kim and colleagues show that OASL1 specifically recognizes IRF7 mRNA and inhibits its translation and the production of type I interferon.

Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells   pp356 - 363
Audrey Gerard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian and Matthew F Krummel
CD8+ T cell are primed via recognition of cognate peptides presented by APCs. Krummel and colleagues show that optimal CD8+ T cell differentiation then occurs via T cell-T cell interactions dependent on the integrin LFA-1.

See also: News and Views by Blair & Dustin

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses   pp364 - 371
Bryan D Bell, Masayuki Kitajima, Ryan P Larson, Thomas A Stoklasek, Kristen Dang, Kazuhito Sakamoto, Kay-Uwe Wagner, Boris Reizis, Lothar Hennighausen and Steven F Ziegler
Thymic stromal lymphopoietin promotes type 2 allergic immune responses via the transcription factor STAT5. Ziegler and colleagues show that ablation of STAT5 in DCs prevents type 2 but not type 1 immunity.

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses   pp372 - 379
Keiji Hirota, Jan-Eric Turner, Matteo Villa, João H Duarte, Jocelyne Demengeot, Oliver M Steinmetz and Brigitta Stockinger
IgA is essential in the maintenance of mucosal host defense and intestinal homeostasis. Stockinger and colleagues show that TH17 cells acquire a follicular helper T cell phenotype in Peyer's patches and induce the development of IgA-producing B cells.

See also: News and Views by Milpied & McHeyzer-Williams

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms   pp380 - 388
Chuanxin Huang, Katerina Hatzi and Ari Melnick
The transcriptional repressor Bcl-6 operates in many hematopoietic lineages. Melnick and colleagues show that Bcl-6 with a mutant BTB corepressor interaction domain selectively impairs B cell effector function.

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway   pp389 - 395
Lucille C Rankin, Joanna R Groom, Michaël Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew N J McKenzie, Sebastian Carotta, Stephen L Nutt and Gabrielle T Belz
NKp46+ innate lymphoid cells are important for the control of gut microbes, but their development is unclear. Belz and colleagues show that they develop from lymphoid tissue-inducer cells in a Notch- and T-bet-dependent manner.

RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila    pp396 - 403
Bertsy Goic, Nicolas Vodovar, Juan A Mondotte, Clément Monot, Lionel Frangeul, Hervé Blanc, Valérie Gausson, Jorge Vera-Otarola, Gael Cristofari and Maria-Carla Saleh
Retrotransposons are often thought of as 'selfish' genetic elements that replicate themselves without any obvious benefit to the host genome. Saleh and colleagues demonstrate that retrotransposons can be involved in generating silencing RNA species to regulate viral replication.

See also: News and Views by Voinnet



Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation   pp404 - 412
J Adam Best, David A Blair, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L Dustin, Ananda W Goldrath and The Immunological Genome Project Consortium
Antigenic activation induces the generation of effector and memory CD8+ T cells. Goldrath and colleagues profile gene expression at various times after infection to identify transcriptional networks unique to each population.



Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells   p413
Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks and Mark J Smyth

Lessons learned from HIV-1 vaccine trials: new priorities and directions   p413
Andrew J McMichael and Barton F Haynes

Re(de)fining the dendritic cell lineage   p413
Ansuman T Satpathy, Xiaodi Wu, Jorn C Albring and Kenneth M Murphy



The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells   p413
Masaki Miyazaki, Richard R Rivera, Kazuko Miyazaki, Yin C Lin, Yasutoshi Agata and Cornelis Murre

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling   p413
Michael P Seiler, Rebecca Mathew, Megan K Liszewski, Chauncey Spooner, Kenneth Barr, Fanyong Meng, Harinder Singh and Albert Bendelac


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