T cell priming goes through a new phase pp311 - 312 David A Blair and Michael L Dustin doi:10.1038/ni.2575 The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8+ T cells requires subsequent T cell-T cell interactions during the critical differentiation period.
High-affinity IgA needs TH17 cell functional plasticity pp313 - 315 Pierre J Milpied and Michael G McHeyzer-Williams doi:10.1038/ni.2567 The conversion of cells of the TH17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor RORγt into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.
How to become your own worst enemy pp315 - 317 Olivier Voinnet doi:10.1038/ni.2571 Persistence is a poorly understood yet widespread outcome of viral infection. A study of RNA viruses in flies now shows that viral fragments endogenized as cDNA during the reverse transcription of retrotransposons provide immunity based on RNA-mediated interference in persistently infected cells.
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